Install via macOS installer#

To install OpenMS on macOS, run the following steps:

  1. Download and install the macOS drag-and-drop installer from the archive.

  2. Double click on the downloaded file. It will start to open the OpenMS-<version>-macOS.dmg disk image file.

Opening OpenMS-<version>-macOS.dmg
  1. Verify the download.

Verifying OpenMS-<version>-macOS.dmg
  1. Agree to the license agreements.

License agreement
  1. Drag OpenMS to the Applications folder.

Move to Applications
  1. It will start copying to applications.

Preparing to copy to Applications Copying to Applications

To use TOPP as regular app in the shell, add the following lines to the ~/.profile file.

source ${OPENMS_TOPP_PATH}/.TOPP_bash_profile

Make sure <OpenMS-PATH> points to the folder where OpenMS is installed locally (e.g., /Applications/OpenMS-<version>)

Install via Conda or Bioconda#

Follow the instructions .

Known Issues#

  1. Nothing happens when you click OpenMS apps or the validity of the developer could not be confirmed.

    This usually means the OpenMS software lands in quarantine after installation of the .dmg. Since macOS Catalina (maybe also Mojave) all apps and executables have to be officially notarized by Apple but we currently do not have the resources for a streamlined notarization workflow.

    To have a streamlined experience without blocking popups, it is recommended to remove the quarantine flag manually, using the following steps:

    Open the and type the following (replace the first line with the actual installation directory):

    cd /Applications/OpenMS-<version>
    sudo xattr -r -d *
  2. Bug with running Java based thirdparty tools like MSGFPlusAdapter and LuciphorAdapter from within

    If you face issues while running Java based thirdparty tools from within, run the from within the (e.g. with the open command) to get access to the path where Java is located. Java is usually present in the PATH of the terminal. Advanced users can set this path in the Info.plist of/inside the